Subacute toxicity experiments in pet dogs for 4 months at 480 mg/kg daily showed no certain improvements; at 960 mg/kg, two out of 8 died with evidence of circulatory collapse. This extensive margin of security is critical compared to chlordiazepoxide HCl, which confirmed nonspecific variations in 6 canines at 80 mg/kg.het lijkt wel of ik placebo h